In non-diabetic clients, mean glucose is usually unremarkable. Variability and fasting regulation are where early dysfunction shows up first. Read in this order:
- SDBG (Standard Deviation of Blood Glucose) — the corridor width; wide swings signal poor glucose regulation.
- Fasting glucose — overnight profile and dawn rise; elevated fasting glucose shows before other markers.
- Post-Meal Peak — glucose rise above pre-meal baseline; exaggerated peaks indicate impaired early-phase insulin response.
- CV (Coefficient of Variation) — day-to-day stability score; comparable across clients with different mean glucose levels.
- Average (Average Sensor Glucose) — the last value to deteriorate; useful as a final check rather than a primary signal.
Source: Shah 2019 [1] — n = 153 healthy adults, 10-day Dexcom G6.
| Metric | Non-diabetic reference | Early-signal zone |
|---|---|---|
| SDBG | ~0.9 mmol/L | >1.2 mmol/L |
| Fasting glucose | 4.5–5.5 mmol/L | ≥ 6.1 mmol/L (see referral triggers) |
| Post-Meal Peak | 1.5–2.5 mmol/L above pre-meal; peak <7.8 | Rise >3.5 mmol/L or peak >8.5 mmol/L |
| CV | 17 ± 3% | >25% |
| Time in Range (TIR) 3.9–7.8 mmol/L | 96% (IQR 93–98) | <90% sustained over 14 days |
| Time Above Range (TAR) >7.8 mmol/L | 2.1% (~30 min/day) | >10% sustained |
| Time Below Range (TBR) <3.9 mmol/L | 1.1% (~15 min/day) | >3% sustained with symptoms |
| Average (sensor glucose) | 5.4–5.5 mmol/L (5.8 if >60 yrs) | Rising trend across consecutive months |
These are screening signals, not diagnoses.
| Signal | Threshold |
|---|---|
| Fasting glucose | ≥ 6.1 mmol/L (Impaired Fasting Glucose) or ≥ 7.0 mmol/L on two separate occasions (diabetic range) |
| Any single sustained reading | ≥ 11.1 mmol/L |
| 14-day average with symptoms | ≥ 6.5 mmol/L |
| Persistent hypoglycaemia | Time Below Range <3.9 mmol/L exceeding 3% with associated symptoms |
Good CGM numbers do not tell the whole story. A client can have Time in Range above 95% and stable CV — and still have a poor lactate profile. Lactate is the next monitoring frontier.
- Fasting lactate can rise before fasting glucose shows any sign of dysfunction [2].
- Mitochondrial dysfunction can be present in lean, insulin-resistant individuals with entirely normal fasting glucose, HbA1c and BMI [3].
Spencer Martin founded Glucose Evolution after 15 years in the CGM industry, having seen first-hand how real-time glucose data transforms outcomes in Type 1 diabetes — and asking why that same insight wasn't being used earlier, before metabolic dysfunction takes hold. Glucose Evolution exists to change that, responsibly and within appropriate scope of practice.